Ontology highlight
ABSTRACT:
SUBMITTER: Matsuki T
PROVIDER: S-EPMC2657380 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Matsuki Taizo T Nomiyama Mika M Takahira Hitomi H Hirashima Noriko N Kunita Satoshi S Takahashi Satoru S Yagami Ken-ichi K Kilduff Thomas S TS Bettler Bernhard B Yanagisawa Masashi M Sakurai Takeshi T
Proceedings of the National Academy of Sciences of the United States of America 20090225 11
Hypothalamic neurons that contain the neuropeptide orexin (hypocretin) play important roles in the regulation of sleep/wake. Here we analyze the in vivo and in vitro phenotype of mice lacking the GABA(B1) gene specifically in orexin neurons (oxGKO mice) and demonstrate that GABA(B) receptors on orexin neurons are essential in stabilizing and consolidating sleep/wake states. In oxGKO brain slices, we show that the absence of GABA(B) receptors decreases the sensitivity of orexin neurons to both ex ...[more]