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Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles.


ABSTRACT: Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.

SUBMITTER: Bouchard LS 

PROVIDER: S-EPMC2657430 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature

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Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles.

Bouchard Louis-S LS   Anwar M Sabieh MS   Liu Gang L GL   Hann Byron B   Xie Z Harry ZH   Gray Joe W JW   Wang Xueding X   Pines Alexander A   Chen Fanqing Frank FF  

Proceedings of the National Academy of Sciences of the United States of America 20090226 11


Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold  ...[more]

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