Control of presynaptic function by a persistent Na(+) current.
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ABSTRACT:
SUBMITTER: Huang H
PROVIDER: S-EPMC2657474 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Publications
Control of presynaptic function by a persistent Na(+) current.
Huang Hai H Trussell Laurence O LO
Neuron 20081201 6
Little is known about ion channels that regulate the graded, subthreshold properties of nerve terminals. Using the calyx of Held, we demonstrate here a large presynaptic persistent Na(+) current with unusually hyperpolarized activation voltage. This feature allowed the current to determine both the resting potential and resting conductance of the nerve terminal. Calyces express presynaptic glycine receptors whose activation depolarizes the synapse. We found that activation of the persistent Na(+ ...[more]
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