Ontology highlight
ABSTRACT:
SUBMITTER: Zaman S
PROVIDER: S-EPMC2657534 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Zaman Shadia S Lippman Soyeon I SI Schneper Lisa L Slonim Noam N Broach James R JR
Molecular systems biology 20090217
Addition of glucose to yeast cells increases their growth rate and results in a massive restructuring of their transcriptional output. We have used microarray analysis in conjunction with conditional mutations to obtain a systems view of the signaling network responsible for glucose-induced transcriptional changes. We found that several well-studied signaling pathways-such as Snf1 and Rgt-are responsible for specialized but limited responses to glucose. However, 90% of the glucose-induced change ...[more]