Ontology highlight
ABSTRACT:
SUBMITTER: Fry AE
PROVIDER: S-EPMC2657869 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Fry A E AE Auburn S S Diakite M M Green A A Richardson A A Wilson J J Jallow M M Sisay-Joof F F Pinder M M Griffiths M J MJ Peshu N N Williams T N TN Marsh K K Molyneux M E ME Taylor T E TE Rockett K A KA Kwiatkowski D P DP
Genes and immunity 20080605 5
Evidence from autopsy and in vitro binding studies suggests that adhesion of erythrocytes infected with Plasmodium falciparum to the human host intercellular adhesion molecule (ICAM)-1 receptor is important in the pathogenesis of severe malaria. Previous association studies between polymorphisms in the ICAM1 gene and susceptibility to severe malarial phenotypes have been inconclusive and often contradictory. We performed genetic association studies with 15 single nucleotide polymorphisms (SNPs) ...[more]