Ontology highlight
ABSTRACT:
SUBMITTER: Clark BR
PROVIDER: S-EPMC2657878 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Clark Benjamin R BR Engene Niclas N Teasdale Margaret E ME Rowley David C DC Matainaho Teatulohi T Valeriote Frederick A FA Gerwick William H WH
Journal of natural products 20080813 9
A Papua New Guinea field collection of the marine cyanobacterium Blennothrix cantharidosmum was investigated for its cytotoxic constituents. Bioassay-guided isolation defined the cytotoxic components as the known compounds lyngbyastatins 1 and 3. However, six new acyl proline derivatives, tumonoic acids D-I, plus the known tumonoic acid A were also isolated. Their planar structures were defined from NMR and MS data, while their stereostructures followed from a series of chiral chromatographies, ...[more]