Chromatin remodeling in the noncoding repeat expansion diseases.
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ABSTRACT:
SUBMITTER: Kumari D
PROVIDER: S-EPMC2658035 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Publications
Chromatin remodeling in the noncoding repeat expansion diseases.
The Journal of biological chemistry 20081028 12
Friedreich ataxia, myotonic dystrophy type 1 and 3 forms of intellectual disability, fragile X syndrome, FRAXE mental retardation, and FRA12A mental retardation are repeat expansion diseases caused by expansion of CTG.CAG, GAA.TTC, or CGG.CCG repeat tracts. These repeats are transcribed but not translated. They are located in different parts of different genes and cause symptoms that range from ataxia and hypertrophic cardiomyopathy to muscle wasting, male infertility, and mental retardation, ye ...[more]
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