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Genome and proteome annotation: organization, interpretation and integration.


ABSTRACT: Recent years have seen a huge increase in the generation of genomic and proteomic data. This has been due to improvements in current biological methodologies, the development of new experimental techniques and the use of computers as support tools. All these raw data are useless if they cannot be properly analysed, annotated, stored and displayed. Consequently, a vast number of resources have been created to present the data to the wider community. Annotation tools and databases provide the means to disseminate these data and to comprehend their biological importance. This review examines the various aspects of annotation: type, methodology and availability. Moreover, it puts a special interest on novel annotation fields, such as that of phenotypes, and highlights the recent efforts focused on the integrating annotations.

SUBMITTER: Reeves GA 

PROVIDER: S-EPMC2658791 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

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Genome and proteome annotation: organization, interpretation and integration.

Reeves Gabrielle A GA   Talavera David D   Thornton Janet M JM  

Journal of the Royal Society, Interface 20090201 31


Recent years have seen a huge increase in the generation of genomic and proteomic data. This has been due to improvements in current biological methodologies, the development of new experimental techniques and the use of computers as support tools. All these raw data are useless if they cannot be properly analysed, annotated, stored and displayed. Consequently, a vast number of resources have been created to present the data to the wider community. Annotation tools and databases provide the mean  ...[more]

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