SUMOylation and De-SUMOylation: wrestling with life's processes.
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ABSTRACT:
SUBMITTER: Yeh ET
PROVIDER: S-EPMC2659178 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Publications
SUMOylation and De-SUMOylation: wrestling with life's processes.
The Journal of biological chemistry 20081113 13
The small ubiquitin-like modifier (SUMO) is a ubiquitin-like protein that covalently modifies a large number of cellular proteins. SUMO modification has emerged as an important regulatory mechanism for protein function and localization. SUMOylation is a dynamic process that is mediated by activating (E1), conjugating (E2), and ligating (E3) enzymes and readily reversed by a family of ubiquitin-like protein-specific proteases (Ulp) in yeast and sentrin/SUMO-specific proteases (SENP) in human. Thi ...[more]
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