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Kinetic complexity of the global response to glucocorticoid receptor action.

ABSTRACT: We have characterized the kinetic response of gene targets throughout the murine genome to transcriptional modulation by the glucocorticoid receptor (GR). In contrast to a model in which multiple genes are either repressed or activated during the GR response, the vast majority of responsive genes are subject to complex regulation profiles, frequently with alternate activation and repression phases. We also observe that GR binding at response elements does not always correlate with the target gene response profile. Thus, the cellular response to GR stimulation involves a highly orchestrated series of regulatory actions and not simply a binary response to hormone.

SUBMITTER: John S

PROVIDER: S-EPMC2659280 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature

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Kinetic complexity of the global response to glucocorticoid receptor action.

John Sam S Johnson Thomas A TA Sung Myong-Hee MH Biddie Simon C SC Trump Saskia S Koch-Paiz Christine A CA Davis Sean R SR Walker Robert R Meltzer Paul S PS Hager Gordon L GL

Endocrinology 20090108 4

We have characterized the kinetic response of gene targets throughout the murine genome to transcriptional modulation by the glucocorticoid receptor (GR). In contrast to a model in which multiple genes are either repressed or activated during the GR response, the vast majority of responsive genes are subject to complex regulation profiles, frequently with alternate activation and repression phases. We also observe that GR binding at response elements does not always correlate with the target gen ...[more]

PMID: 19131569

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