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Cancer genetic association studies in the genome-wide age.


ABSTRACT: Genome-wide association studies of hundreds of thousands of SNPs have led to a deluge of studies of genetic variation in cancer and other common diseases. Large case-control and cohort studies have identified novel SNPs as markers of cancer risk. Genome-wide association study SNP data have also advanced understanding of population-specific genetic variation. While studies of risk profiles, combinations of SNPs that may increase cancer risk, are not yet clinically applicable, future, large-scale studies will make individualized cancer screening and prevention possible.

SUBMITTER: Savage SA 

PROVIDER: S-EPMC2659339 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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Cancer genetic association studies in the genome-wide age.

Savage Sharon A SA  

Personalized medicine 20081101 6


Genome-wide association studies of hundreds of thousands of SNPs have led to a deluge of studies of genetic variation in cancer and other common diseases. Large case-control and cohort studies have identified novel SNPs as markers of cancer risk. Genome-wide association study SNP data have also advanced understanding of population-specific genetic variation. While studies of risk profiles, combinations of SNPs that may increase cancer risk, are not yet clinically applicable, future, large-scale  ...[more]

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