Ontology highlight
ABSTRACT:
SUBMITTER: Chaban Y
PROVIDER: S-EPMC2659406 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Chaban Yuriy Y Ezeokonkwo Chukwudi C Chung Wen-Hsiang WH Zhang Fan F Kornberg Roger D RD Maier-Davis Barbara B Lorch Yahli Y Asturias Francisco J FJ
Nature structural & molecular biology 20081123 12
ATP-dependent chromatin-remodeling complexes, such as RSC, can reposition, evict or restructure nucleosomes. A structure of a RSC-nucleosome complex with a nucleosome determined by cryo-EM shows the nucleosome bound in a central RSC cavity. Extensive interaction of RSC with histones and DNA seems to destabilize the nucleosome and lead to an overall ATP-independent rearrangement of its structure. Nucleosomal DNA appears disordered and largely free to bulge out into solution as required for remode ...[more]