Extensive HIV-1 intra-host recombination is common in tissues with abnormal histopathology.
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ABSTRACT:
SUBMITTER: Lamers SL
PROVIDER: S-EPMC2659430 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
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Extensive HIV-1 intra-host recombination is common in tissues with abnormal histopathology.
Lamers Susanna L SL Salemi Marco M Galligan Derek C DC de Oliveira Tulio T Fogel Gary B GB Granier Sara C SC Zhao Li L Brown Joseph N JN Morris Alanna A Masliah Eliezer E McGrath Michael S MS
PloS one 20090331 3
There is evidence that immune-activated macrophages infected with the Human Immunodeficiency Virus (HIV) are associated with tissue damage and serve as a long-lived viral reservoir during therapy. In this study, we analyzed 780 HIV genetic sequences generated from 53 tissues displaying normal and abnormal histopathology. We found up to 50% of the sequences from abnormal lymphoid and macrophage rich non-lymphoid tissues were intra-host viral recombinants. The presence of extensive recombination, ...[more]
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