Ontology highlight
ABSTRACT:
SUBMITTER: Slattery ML
PROVIDER: S-EPMC2659563 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Slattery Martha L ML Herrick Jennifer J Wolff Roger K RK Caan Bette J BJ Potter John D JD Sweeney Carol C
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20071201 12
Studies suggest that polymorphisms of the vitamin D receptor (VDR) gene may influence colorectal cancer risk. In this study, we examine the association of the CDX2 VDR polymorphism (rs11568820) located in the 5'-untranslated region of the gene, and VDR haplotypes, including this polymorphism, with colon and rectal cancer using data from two large case-control studies of colon (N = 1,574 cases and 1,970 controls) and rectal (n = 791 cases and 999 controls) cancer. The frequency of the A allele of ...[more]