Ontology highlight
ABSTRACT:
SUBMITTER: Mallavarapu A
PROVIDER: S-EPMC2659579 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Mallavarapu Aneil A Thomson Matthew M Ullian Benjamin B Gunawardena Jeremy J
Journal of the Royal Society, Interface 20090301 32
Mathematical models are increasingly used to understand how phenotypes emerge from systems of molecular interactions. However, their current construction as monolithic sets of equations presents a fundamental barrier to progress. Overcoming this requires modularity, enabling sub-systems to be specified independently and combined incrementally, and abstraction, enabling generic properties of biological processes to be specified independently of specific instances. These, in turn, require models t ...[more]