Ontology highlight
ABSTRACT:
SUBMITTER: Shah YM
PROVIDER: S-EPMC2659630 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Shah Yatrik M YM Matsubara Tsutomu T Ito Shinji S Yim Sun-Hee SH Gonzalez Frank J FJ
Cell metabolism 20090115 2
Iron deficiency and iron overload are among the most prevalent nutritional disorders worldwide. Duodenal cytochrome b (DcytB) and divalent metal transporter 1 (DMT1) are regulators of iron absorption. Their expression is increased during high systemic requirements for iron, but the molecular mechanisms that regulate DcytB and DMT1 expression are undefined. Hypoxia-inducible factor (HIF) signaling was induced in the intestine following acute iron deficiency in the duodenum, resulting in activatio ...[more]