Ontology highlight
ABSTRACT:
SUBMITTER: Dullaers M
PROVIDER: S-EPMC2659635 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Dullaers Melissa M Li Dapeng D Xue Yaming Y Ni Ling L Gayet Ingrid I Morita Rimpei R Ueno Hideki H Palucka Karolina Anna KA Banchereau Jacques J Oh Sangkon S
Immunity 20090101 1
Mucosal immunoglobulin A (IgA) secreted by local plasma cells (PCs) is a critical component of mucosal immunity. Although IgA class switching can occur at mucosal sites, high-affinity PCs are optimally generated in germinal centers (GCs) in a T cell-dependent fashion. However, how CD4(+) helper T cells induce mucosal-homing IgA-PCs remains unclear. Here, we show that transforming growth factor beta1 (TGFbeta1) and interleukin 21 (IL-21), produced by follicular helper T cells (Tfh), synergized to ...[more]