Ontology highlight
ABSTRACT:
SUBMITTER: Taddei I
PROVIDER: S-EPMC2659707 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Taddei Ilaria I Deugnier Marie-Ange MA Faraldo Marisa M MM Petit Valérie V Bouvard Daniel D Medina Daniel D Fässler Reinhard R Thiery Jean Paul JP Glukhova Marina A MA
Nature cell biology 20080511 6
The mammary gland epithelium comprises two major cell types: basal and luminal. Basal cells interact directly with the extracellular matrix (ECM) and express higher levels of the ECM receptors, integrins, than luminal cells. We show that deletion of beta1 integrin from basal cells abolishes the regenerative potential of the mammary epithelium and affects mammary gland development. The mutant epithelium was characterized by an abnormal ductal branching pattern and aberrant morphogenesis in pregna ...[more]