Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC2659786 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Yang Xiaojing X Karuturi R K Murthy RK Sun Feng F Aau Meiyee M Yu Kun K Shao Rongguang R Miller Lance D LD Tan Patrick Boon Ooi PB Yu Qiang Q
PloS one 20090402 4
CDKN1C (encoding tumor suppressor p57(KIP2)) is a cyclin-dependent kinase (CDK) inhibitor whose family members are often transcriptionally downregulated in human cancer via promoter DNA methylation. In this study, we show that CDKN1C is repressed in breast cancer cells mainly through histone modifications. In particular, we show that CDKN1C is targeted by histone methyltransferase EZH2-mediated histone H3 lysine 27 trimethylation (H3K27me3), and can be strongly activated by inhibition of EZH2 in ...[more]