Ontology highlight
ABSTRACT:
SUBMITTER: Vuononvirta R
PROVIDER: S-EPMC2659869 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Vuononvirta Raisa R Sebire Neil J NJ Dallosso Anthony R AR Reis-Filho Jorge S JS Williams Richard D RD Mackay Alan A Fenwick Kerry K Grigoriadis Anita A Ashworth Alan A Pritchard-Jones Kathy K Brown Keith W KW Vujanic Gordan M GM Jones Chris C
Clinical cancer research : an official journal of the American Association for Cancer Research 20081201 23
<h4>Purpose</h4>Perilobar nephrogenic rests (PLNRs) are abnormally persistent foci of embryonal immature blastema that have been associated with dysregulation at the 11p15 locus by genetic/epigenetic means and are thought to be precursor lesions of Wilms tumor. The precise genomic events are, however, largely unknown.<h4>Experimental design</h4>We used array comparative genomic hybridization to analyze a series of 50 PLNRs and 25 corresponding Wilms tumors characterized for 11p15 genetic/epigene ...[more]