Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC2660144 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Li Siming S Arning Erland E Liu Chang C Vitvitsky Victor V Hernandez Carlos C Banerjee Ruma R Bottiglieri Teodoro T Lin Jiandie D JD
American journal of physiology. Endocrinology and metabolism 20090121 3
Plasma homocysteine (Hcy) is an independent risk factor for cardiovascular disease. Hcy is a nonprotein amino acid derivative that is generated from the methionine cycle, which provides the methyl group for essentially all biological methylation reactions. Although plasma Hcy levels are elevated in patients with cardiovascular disease, the mechanisms that regulate Hcy homeostasis remain poorly defined. In this study, we found that the expression of key enzymes involved in Hcy metabolism is induc ...[more]