Subclinical inflammation and diabetic polyneuropathy: MONICA/KORA Survey F3 (Augsburg, Germany).
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ABSTRACT: Objective
Subclinical inflammation represents a risk factor of type 2 diabetes and several diabetes complications, but data on diabetic neuropathies are scarce. Therefore, we investigated whether circulating concentrations of acute-phase proteins, cytokines, and chemokines differ among diabetic patients with or without diabetic polyneuropathy.Research design and methods
We measured 10 markers of subclinical inflammation in 227 type 2 diabetic patients with diabetic polyneuropathy who participated in the population-based MONICA/KORA Survey F3 (2004-2005; Augsburg, Germany). Diabetic polyneuropathy was diagnosed using the Michigan Neuropathy Screening Instrument (MNSI).Results
After adjustment for multiple confounders, high levels of C-reactive protein and interleukin (IL)-6 were most consistently associated with diabetic polyneuropathy, high MNSI score, and specific neuropathic deficits, whereas some inverse associations were seen for IL-18.Conclusions
This study shows that subclinical inflammation is associated with diabetic polyneuropathy and neuropathic impairments. This association appears rather specific because only certain immune mediators and impairments are involved.
SUBMITTER: Herder C
PROVIDER: S-EPMC2660451 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Publications
Subclinical inflammation and diabetic polyneuropathy: MONICA/KORA Survey F3 (Augsburg, Germany).
Herder Christian C Lankisch Mark M Ziegler Dan D Rathmann Wolfgang W Koenig Wolfgang W Illig Thomas T Döring Angela A Thorand Barbara B Holle Rolf R Giani Guido G Martin Stephan S Meisinger Christa C
Diabetes care 20090108 4
<h4>Objective</h4>Subclinical inflammation represents a risk factor of type 2 diabetes and several diabetes complications, but data on diabetic neuropathies are scarce. Therefore, we investigated whether circulating concentrations of acute-phase proteins, cytokines, and chemokines differ among diabetic patients with or without diabetic polyneuropathy.<h4>Research design and methods</h4>We measured 10 markers of subclinical inflammation in 227 type 2 diabetic patients with diabetic polyneuropathy ...[more]
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