Ontology highlight
ABSTRACT:
SUBMITTER: Moussawi K
PROVIDER: S-EPMC2661026 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Moussawi Khaled K Pacchioni Alejandra A Moran Megan M Olive M Foster MF Gass Justin T JT Lavin Antonieta A Kalivas Peter W PW
Nature neuroscience 20090111 2
Cocaine addiction is characterized by an impaired ability to develop adaptive behaviors that can compete with cocaine seeking, implying a deficit in the ability to induce plasticity in cortico-accumbens circuitry crucial for regulating motivated behavior. We found that rats withdrawn from cocaine self-administration had a marked in vivo deficit in the ability to develop long-term potentiation (LTP) and long-term depression (LTD) in the nucleus accumbens core subregion after stimulation of the pr ...[more]