Ontology highlight
ABSTRACT:
SUBMITTER: Newhouse S
PROVIDER: S-EPMC2661139 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Newhouse Stephen S Farrall Martin M Wallace Chris C Hoti Mimoza M Burke Beverley B Howard Philip P Onipinla Abiodun A Lee Kate K Shaw-Hawkins Sue S Dobson Richard R Brown Morris M Samani Nilesh J NJ Dominiczak Anna F AF Connell John M JM Lathrop G Mark GM Kooner Jaspal J Chambers John J Elliott Paul P Clarke Robert R Collins Rory R Laan Maris M Org Elin E Org Elin E Juhanson Peeter P Veldre Gudrun G Viigimaa Margus M Eyheramendy Susana S Cappuccio Francesco P FP Ji Chen C Iacone Roberto R Strazzullo Pasquale P Kumari Meena M Marmot Michael M Brunner Eric E Caulfield Mark M Munroe Patricia B PB
PloS one 20090404 4
WNK1--a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control--is an excellent candidate gene for essential hypertension (EH). We and others have previously reported association between WNK1 and BP variation. Using tag SNPs (tSNPs) that capture 100% of common WNK1 variation in HapMap, we aimed to replicate our findings with BP and to test for association with phenotypes relating to WNK1 function in the British Genetics of Hypertension (BRIGHT) study case-con ...[more]