Ontology highlight
ABSTRACT:
SUBMITTER: Strauch EM
PROVIDER: S-EPMC2661573 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Strauch Eva-Maria EM Georgiou George G
Journal of molecular biology 20070922 2
In vitro studies have suggested that the TatBC complex serves as the receptor for signal peptides targeted for export via the twin-arginine translocation (Tat) pathway. Substitution of the hallmark twin-arginine dipeptide with two lysines abrogates export of physiological substrates in all organisms. We report the isolation and characterization of suppressor mutations that allow export of an ssTor(KK)-GFP-SsrA tripartite fusion. We identified two amino acid suppressor mutations in the first cyto ...[more]