A novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosis.
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ABSTRACT:
SUBMITTER: Sahoo A
PROVIDER: S-EPMC2662000 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
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A novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosis.
Sahoo Anupama A Jung Yun Min YM Kwon Ho-Keun HK Yi Hwa-Jung HJ Lee Suho S Chang Sunghoe S Park Zee-Yong ZY Hwang Ki-Chul KC Im Sin-Hyeog SH
The Journal of biological chemistry 20080815 43
Alternative splicing of mRNA enables functionally diverse protein isoforms to be expressed from a single gene, allowing transcriptome diversification. Interleukin (IL)-24/MDA-7 is a member of the IL-10 gene family, and FISP (IL-4-induced secreted protein), its murine homologue, is selectively expressed and secreted by T helper 2 lymphocytes. A novel splice variant of mouse IL-24/FISP, designated FISP-sp, lacks 29 nucleotides from the 5'-end of exon 4 of FISP. The level of FISP-sp expression is 1 ...[more]
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