Ontology highlight
ABSTRACT:
SUBMITTER: Wang K
PROVIDER: S-EPMC2662224 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Wang Kepeng K Wang Chihao C Xiao Fang F Wang Haixia H Wu Zhenguo Z Wu Zhenguo Z
The Journal of biological chemistry 20081002 49
Skeletal muscle satellite cell-derived myoblasts are mainly responsible for postnatal muscle growth and injury-induced regeneration. However, the cellular signaling pathways that control proliferation and differentiation of myoblasts remain poorly defined. Recently, we found that JAK1/STAT1/STAT3 not only participate in myoblast proliferation but also actively prevent them from premature differentiation. Unexpectedly, we found that a related pathway consisting of JAK2, STAT2, and STAT3 is requir ...[more]