Ontology highlight
ABSTRACT:
SUBMITTER: Li YH
PROVIDER: S-EPMC2662285 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Li Ying-Hua YH Werner Hendrikje H Püschel Andreas W AW
The Journal of biological chemistry 20081008 48
The development of polarized hippocampal neurons with a single axon and multiple dendrites depends on the activity of phosphoinositide 3-kinase (PI3K) and the GTPase Rap1B. Here we show that PI3K regulates axon specification and elongation through the GTPase Rheb and its target mammalian target of rapamycin (mTOR). Overexpression of Rheb induces the formation of multiple axons, whereas its suppression by RNA interference blocks axon specification. mTOR is a central regulator of translation that ...[more]