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Proteomic analysis of the hyaloid vascular system regression during ocular development.


ABSTRACT: We describe a proteomic approach to investigate the differential protein expression patterns and identify the physiologically relevant angiogenic and antiangiogenic factors involved in the hyaloid vascular system regression. Differentially expressed proteins were identified using two-dimensional gel electrophoresis followed by nanoflow chromatography coupled with tandem mass spectrometry. These proteins are expected to provide insight as to their function in the early maintenance and eventual regression of the hyaloid vascular system.

SUBMITTER: Albe E 

PROVIDER: S-EPMC2662928 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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Proteomic analysis of the hyaloid vascular system regression during ocular development.

Albè Elena E   Chang Jin-Hong JH   Azar Nathalie F NF   Ivanov Alexander R AR   Azar Dimitri T DT  

Journal of proteome research 20081008 11


We describe a proteomic approach to investigate the differential protein expression patterns and identify the physiologically relevant angiogenic and antiangiogenic factors involved in the hyaloid vascular system regression. Differentially expressed proteins were identified using two-dimensional gel electrophoresis followed by nanoflow chromatography coupled with tandem mass spectrometry. These proteins are expected to provide insight as to their function in the early maintenance and eventual re  ...[more]

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