Detection of respiratory syncytial virus in adults with chronic obstructive pulmonary disease.

ABSTRACT:

Rationale

Recently, respiratory syncytial virus (RSV) RNA has been identified by reverse transcriptase-polymerase chain reaction (RT-PCR) from a high percentage of patients with stable chronic obstructive pulmonary disease (COPD). These data raise the possibility of persistent low-grade infection in this population, which could have implications in COPD pathogenesis.

Objectives

RSV persistence was investigated by testing respiratory secretions from subjects with COPD during illness and at regular intervals over 1 yr.

Methods

Nasal and sputum samples from subjects with COPD were tested by one-tube nested RT-PCR for RSV every 2 mo and during respiratory illnesses for 1 yr. Subjects positive for RSV were evaluated weekly until negative in two consecutive samples. Nasal s

SUBMITTER: Falsey AR 

PROVIDER: S-EPMC2662947 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature