Ontology highlight
ABSTRACT:
SUBMITTER: Vargesson N
PROVIDER: S-EPMC2663054 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
PloS one 20090408 4
The inhibitory or negative Smads, Smad6 and Smad7, block TGFbeta superfamily signals of both the BMP and TGFbeta classes by antagonizing the intracellular signal transduction machinery. We report the cloning of one Smad6 and two Smad7 (Smad7a and Smad7b) chick homologs and their expression and regulation in the developing limb. Smad6 and Smad7a are expressed in dynamic patterns reflecting the domains of BMP gene expression in the limb. Activation and inhibition of the BMP signaling pathway in li ...[more]