Transcriptional signature following inhibition of early-stage cell wall biosynthesis in Staphylococcus aureus.
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ABSTRACT:
SUBMITTER: O'Neill AJ
PROVIDER: S-EPMC2663120 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Publications
Transcriptional signature following inhibition of early-stage cell wall biosynthesis in Staphylococcus aureus.
O'Neill A J AJ Lindsay J A JA Gould K K Hinds J J Chopra I I
Antimicrobial agents and chemotherapy 20090121 4
To facilitate mode of action studies on antibacterial inhibitors of early-stage cell wall biosynthesis (CWB), we determined the transcriptional response of Staphylococcus aureus to depletion/inhibition of enzymes in this pathway by DNA microarray analysis. We identified a transcriptional signature distinct from that previously observed following exposure to inhibitors of late-stage CWB. ...[more]
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