Ontology highlight
ABSTRACT:
SUBMITTER: Kugel D
PROVIDER: S-EPMC2663257 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Kugel Daniela D Kochs Georg G Obojes Karola K Roth Joachim J Kobinger Gary P GP Kobasa Darwyn D Haller Otto O Staeheli Peter P von Messling Veronika V
Journal of virology 20090204 8
The type I interferon (IFN) response represents one of the first lines of defense against influenza virus infections. In this study, we assessed the protective potential of exogenous IFN-alpha against seasonal and highly pathogenic influenza viruses in ferrets. Intranasal treatment with IFN-alpha several hours before infection with the H1N1 influenza A virus strain A/USSR/90/77 reduced viral titers in nasal washes at least 100-fold compared to mock-treated controls. IFN-treated animals developed ...[more]