Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh TK
PROVIDER: S-EPMC2663302 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Ghosh Tushar K TK Song Fei Fei FF Packham Elizabeth A EA Buxton Sarah S Robinson Thelma E TE Ronksley Jonathan J Self Tim T Bonser Andrew J AJ Brook J David JD
Molecular and cellular biology 20090209 8
TBX5 is a transcription factor which plays important roles in the development of the heart and upper limbs. Mutations in this gene produce the inherited disorder Holt-Oram syndrome. Here, we report a physical interaction between TBX5 and MEF2C leading to a synergistic activation of the alpha-cardiac myosin heavy chain (MYH6). Mutants of TBX5, TBX5G80R, and TBX5R279X that produce severe cardiac phenotypes impair the synergy. Using fluorescence resonance energy transfer, we demonstrate the interac ...[more]