Ontology highlight
ABSTRACT:
SUBMITTER: Paulick MG
PROVIDER: S-EPMC2663890 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Paulick Margot G MG Bertozzi Carolyn R CR
Biochemistry 20080617 27
Positioned at the C-terminus of many eukaryotic proteins, the glycosylphosphatidylinositol (GPI) anchor is a posttranslational modification that anchors the modified protein in the outer leaflet of the cell membrane. The GPI anchor is a complex structure comprising a phosphoethanolamine linker, glycan core, and phospholipid tail. GPI-anchored proteins are structurally and functionally diverse and play vital roles in numerous biological processes. While several GPI-anchored proteins have been cha ...[more]