Ontology highlight
ABSTRACT:
SUBMITTER: Chiasson CM
PROVIDER: S-EPMC2663933 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Chiasson Christine M CM Wittich Kristin B KB Vincent Peter A PA Faundez Victor V Kowalczyk Andrew P AP
Molecular biology of the cell 20090211 7
p120-catenin is a cytoplasmic binding partner of cadherins and functions as a set point for cadherin expression by preventing cadherin endocytosis, and degradation. p120 is known to regulate cell motility and invasiveness by inhibiting RhoA activity. However, the relationship between these functions of p120 is not understood. Here, we provide evidence that p120 functions as part of a plasma membrane retention mechanism for VE-cadherin by preventing the recruitment of VE-cadherin into membrane do ...[more]