Ontology highlight
ABSTRACT:
SUBMITTER: Birley AJ
PROVIDER: S-EPMC2664151 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Birley Andrew J AJ James Michael R MR Dickson Peter A PA Montgomery Grant W GW Heath Andrew C AC Martin Nicholas G NG Whitfield John B JB
Human molecular genetics 20090204 8
We have previously found that variation in alcohol metabolism in Europeans is linked to the chromosome 4q region containing the ADH gene family. We have now typed 103 single nucleotide polymorphisms (SNPs) across this region to test for allelic associations with variation in blood and breath alcohol concentrations after an alcohol challenge. In vivo alcohol metabolism was modelled with three parameters that identified the absorption and rise of alcohol concentration following ingestion, and the ...[more]