Ontology highlight
ABSTRACT:
SUBMITTER: Rocca DL
PROVIDER: S-EPMC2664613 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Rocca Daniel L DL Martin Stéphane S Jenkins Emma L EL Hanley Jonathan G JG
Nature cell biology 20080224 3
The dynamic regulation of actin polymerization plays crucial roles in cell morphology and endocytosis. The mechanistic details of these processes and the proteins involved are not fully understood, especially in neurons. PICK1 is a PDZ-BAR-domain protein involved in regulated AMPA receptor (AMPAR) endocytosis in neurons. Here, we demonstrate that PICK1 binds filamentous (F)-actin and the actin-nucleating Arp2/3 complex, and potently inhibits Arp2/3-mediated actin polymerization. RNA interference ...[more]