Ontology highlight
ABSTRACT:
SUBMITTER: Olson LE
PROVIDER: S-EPMC2664622 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Olson Lorin E LE Soriano Philippe P
Developmental cell 20090201 2
PDGF signaling regulates the development of mesenchymal cell types in the embryo and in the adult, but the role of receptor activation in tissue homeostasis has not been investigated. We have generated conditional knockin mice with mutations in PDGFRalpha that drive increased kinase activity under the control of the endogenous PDGFRalpha promoter. In embryos, increased PDGFRalpha signaling leads to hyperplasia of stromal fibroblasts, which disturbs normal smooth muscle tissue in radially pattern ...[more]