Ontology highlight
ABSTRACT:
SUBMITTER: Padera TP
PROVIDER: S-EPMC2664998 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Padera Timothy P TP Kuo Angera H AH Hoshida Tohru T Liao Shan S Lobo Jennifer J Kozak Kevin R KR Fukumura Dai D Jain Rakesh K RK
Molecular cancer therapeutics 20080806 8
Blood vessels are required for a tumor to grow and functional lymphatic vessels are required for it to disseminate to lymph nodes. In an attempt to eradicate both the primary tumor and its lymphatic metastasis, we targeted both blood and lymphatic vessels using two different tyrosine kinase inhibitors (TKIs): cediranib and vandetanib, which block vascular endothelial growth factor receptor (VEGFR)-2 and -3 in enzymatic assays. We found that although both cediranib and vandetanib slowed the growt ...[more]