Ontology highlight
ABSTRACT:
SUBMITTER: Luong MX
PROVIDER: S-EPMC2665001 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Luong Mai X MX Tam Joshua J Lin Qingcong Q Hagendoorn Jeroen J Moore Kathryn J KJ Padera Timothy P TP Seed Brian B Fukumura Dai D Kucherlapati Raju R Jain Rakesh K RK
Journal of cellular physiology 20090501 2
Lymphatic vessels play a key role in maintaining tissue-fluid homeostasis, immune surveillance and metastasis. The hyaluronan receptor, LYVE-1, is widely used as a molecular marker for adult and embryonic lymphatic endothelium, but its physiological functions have not yet been established in vivo. In agreement with a recent report, LYVE-1(-/-) mice, which are healthy and fertile, do not display any defects related to congenital abnormalities of the lymphatic system. One hypothesis for the absenc ...[more]