Ontology highlight
ABSTRACT:
SUBMITTER: Moreno PM
PROVIDER: S-EPMC2665231 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Moreno Pedro M D PM Wenska Malgorzata M Lundin Karin E KE Wrange Orjan O Strömberg Roger R Smith C I Edvard CI
Nucleic acids research 20090210 6
Accessing the nucleus through the surrounding membrane poses one of the major obstacles for therapeutic molecules large enough to be excluded due to nuclear pore size limits. In some therapeutic applications the large size of some nucleic acids, like plasmid DNA, hampers their access to the nuclear compartment. However, also for small oligonucleotides, achieving higher nuclear concentrations could be of great benefit. We report on the synthesis and possible applications of a natural RNA 5'-end n ...[more]