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Multicomponent synthesis of alpha-branched amides.

ABSTRACT: Alpha-branched amides are prepared by multicomponent reactions in which nitriles undergo hydrozirconation to form metalloimines that react with acyl chlorides. The resulting acylimines react with a variety of pi-nucleophiles in the presence of Lewis acids to form the desired amides.

SUBMITTER: DeBenedetto MV

PROVIDER: S-EPMC2665885 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

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Multicomponent synthesis of alpha-branched amides.

DeBenedetto Mikkel V MV Green Michael E ME Wan Shuangyi S Park Jung-Hyun JH Floreancig Paul E PE

Organic letters 20090201 4

Alpha-branched amides are prepared by multicomponent reactions in which nitriles undergo hydrozirconation to form metalloimines that react with acyl chlorides. The resulting acylimines react with a variety of pi-nucleophiles in the presence of Lewis acids to form the desired amides. ...[more]

PMID: 19152262

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