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Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial.


ABSTRACT: The effectiveness of intentional weight loss in reducing cardiovascular disease (CVD) events in type 2 diabetes is unknown. This report describes 1-year changes in CVD risk factors in a trial designed to examine the long-term effects of an intensive lifestyle intervention on the incidence of major CVD events.This study consisted of a multicentered, randomized, controlled trial of 5,145 individuals with type 2 diabetes, aged 45-74 years, with BMI >25 kg/m2 (>27 kg/m2 if taking insulin). An intensive lifestyle intervention (ILI) involving group and individual meetings to achieve and maintain weight loss through decreased caloric intake and increased physical activity was compared with a diabetes support and education (DSE) condition.Participants assigned to ILI lost an average 8.6% of their initial weight vs. 0.7% in DSE group (P < 0.001). Mean fitness increased in ILI by 20.9 vs. 5.8% in DSE (P < 0.001). A greater proportion of ILI participants had reductions in diabetes, hypertension, and lipid-lowering medicines. Mean A1C dropped from 7.3 to 6.6% in ILI (P < 0.001) vs. from 7.3 to 7.2% in DSE. Systolic and diastolic pressure, triglycerides, HDL cholesterol, and urine albumin-to-creatinine ratio improved significantly more in ILI than DSE participants (all P < 0.01).At 1 year, ILI resulted in clinically significant weight loss in people with type 2 diabetes. This was associated with improved diabetes control and CVD risk factors and reduced medicine use in ILI versus DSE. Continued intervention and follow-up will determine whether these changes are maintained and will reduce CVD risk.

SUBMITTER: Look AHEAD Research Group 

PROVIDER: S-EPMC2665929 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature

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Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial.

Pi-Sunyer Xavier X   Blackburn George G   Brancati Frederick L FL   Bray George A GA   Bright Renee R   Clark Jeanne M JM   Curtis Jeffrey M JM   Espeland Mark A MA   Foreyt John P JP   Graves Kathryn K   Haffner Steven M SM   Harrison Barbara B   Hill James O JO   Horton Edward S ES   Jakicic John J   Jeffery Robert W RW   Johnson Karen C KC   Kahn Steven S   Kelley David E DE   Kitabchi Abbas E AE   Knowler William C WC   Lewis Cora E CE   Maschak-Carey Barbara J BJ   Montgomery Brenda B   Nathan David M DM   Patricio Jennifer J   Peters Anne A   Redmon J Bruce JB   Reeves Rebecca S RS   Ryan Donna H DH   Safford Monika M   Van Dorsten Brent B   Wadden Thomas A TA   Wagenknecht Lynne L   Wesche-Thobaben Jacqueline J   Wing Rena R RR   Yanovski Susan Z SZ  

Diabetes care 20070315 6


<h4>Objective</h4>The effectiveness of intentional weight loss in reducing cardiovascular disease (CVD) events in type 2 diabetes is unknown. This report describes 1-year changes in CVD risk factors in a trial designed to examine the long-term effects of an intensive lifestyle intervention on the incidence of major CVD events.<h4>Research design and methods</h4>This study consisted of a multicentered, randomized, controlled trial of 5,145 individuals with type 2 diabetes, aged 45-74 years, with  ...[more]

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