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Reduced reaction frequencies with repeated inactivated or live-attenuated influenza vaccination.


ABSTRACT: Data collected as part of a multi-year trial examining the efficacies of inactivated and live-attenuated influenza vaccines were used to evaluate the reported occurrence of post-vaccination reactions. Two cohorts were defined: (1) individuals who received the same vaccine over two consecutive years, and (2) individuals who first enrolled in year 2 of the study and received vaccine only in that year. For both vaccines there were significantly fewer reactions reported in year 2 in those subjects who were vaccinated both years. Declines were demonstrated when comparing year 1 and 2 reaction frequencies in subjects vaccinated both years, and differences were seen when comparing year 2 reaction frequencies in subjects vaccinated both years with those first vaccinated in year 2. Reaction reporting peaked on post-vaccination days 0 and 1 following receipt of the inactivated vaccine, and on day 2 following receipt of the live-attenuated vaccine.

SUBMITTER: Ohmit SE 

PROVIDER: S-EPMC2665993 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

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Reduced reaction frequencies with repeated inactivated or live-attenuated influenza vaccination.

Ohmit Suzanne E SE   Gross Jonathan J   Victor John C JC   Monto Arnold S AS  

Vaccine 20081216 7


Data collected as part of a multi-year trial examining the efficacies of inactivated and live-attenuated influenza vaccines were used to evaluate the reported occurrence of post-vaccination reactions. Two cohorts were defined: (1) individuals who received the same vaccine over two consecutive years, and (2) individuals who first enrolled in year 2 of the study and received vaccine only in that year. For both vaccines there were significantly fewer reactions reported in year 2 in those subjects w  ...[more]

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