Mechanisms of sleep-dependent consolidation of cortical plasticity.
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ABSTRACT:
SUBMITTER: Aton SJ
PROVIDER: S-EPMC2665998 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Publications
Mechanisms of sleep-dependent consolidation of cortical plasticity.
Aton Sara J SJ Seibt Julie J Dumoulin Michelle M Jha Sushil K SK Steinmetz Nicholas N Coleman Tammi T Naidoo Nirinjini N Frank Marcos G MG
Neuron 20090201 3
Sleep is thought to consolidate changes in synaptic strength, but the underlying mechanisms are unknown. We investigated the cellular events involved in this process during ocular dominance plasticity (ODP)-a canonical form of in vivo cortical plasticity triggered by monocular deprivation (MD) and consolidated by sleep via undetermined, activity-dependent mechanisms. We find that sleep consolidates ODP primarily by strengthening cortical responses to nondeprived eye stimulation. Consolidation is ...[more]
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