Ontology highlight
ABSTRACT:
SUBMITTER: Carson CT
PROVIDER: S-EPMC2666027 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Carson Christian T CT Orazio Nicole I NI Lee Darwin V DV Suh Junghae J Bekker-Jensen Simon S Araujo Felipe D FD Lakdawala Seema S SS Lilley Caroline E CE Bartek Jiri J Lukas Jiri J Weitzman Matthew D MD
The EMBO journal 20090205 6
The protein kinases ataxia-telangiectasia mutated (ATM) and ATM-Rad3 related (ATR) are activated in response to DNA damage, genotoxic stress and virus infections. Here we show that during infection with wild-type adenovirus, ATR and its cofactors RPA32, ATRIP and TopBP1 accumulate at viral replication centres, but there is minimal ATR activation. We show that the Mre11/Rad50/Nbs1 (MRN) complex is recruited to viral centres only during infection with adenoviruses lacking the early region E4 and A ...[more]