Ontology highlight
ABSTRACT:
SUBMITTER: Terrenoire C
PROVIDER: S-EPMC2666564 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Terrenoire Cecile C Houslay Miles D MD Baillie George S GS Kass Robert S RS
The Journal of biological chemistry 20090213 14
The cardiac I(Ks) potassium channel is a macromolecular complex consisting of alpha-(KCNQ1) and beta-subunits (KCNE1) and the A kinase-anchoring protein (AKAP) Yotiao (AKAP-9), which recruits protein kinase A) and protein phosphatase 1 to the channel. Here, we have tested the hypothesis that specific cAMP phosphodiesterase (PDE) isoforms of the PDE4D family that are expressed in the heart are also part of the I(Ks) signaling complex and contribute to its regulation by cAMP. PDE4D isoforms co-imm ...[more]