Ontology highlight
ABSTRACT:
SUBMITTER: Huertas P
PROVIDER: S-EPMC2666608 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Huertas Pablo P Jackson Stephen P SP
The Journal of biological chemistry 20090207 14
In G(0) and G(1), DNA double strand breaks are repaired by nonhomologous end joining, whereas in S and G(2), they are also repaired by homologous recombination. The human CtIP protein controls double strand break (DSB) resection, an event that occurs effectively only in S/G(2) and that promotes homologous recombination but not non-homologous end joining. Here, we mutate a highly conserved cyclin-dependent kinase (CDK) target motif in CtIP and reveal that mutating Thr-847 to Ala impairs resection ...[more]