Ontology highlight
ABSTRACT:
SUBMITTER: Wolff K
PROVIDER: S-EPMC2666633 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Wolff Katrin K Vendruscolo Michele M Porto Markus M
PMC biophysics 20081126 1
We discuss a stochastic approach for reconstructing the native structures of proteins from the knowledge of the "effective connectivity", which is a one-dimensional structural profile constructed as a linear combination of the eigenvectors of the contact map of the target structure. The structural profile is used to bias a search of the conformational space towards the target structure in a Monte Carlo scheme operating on a Calpha-chain of uniform, finite thickness. Structure information thus en ...[more]